I just know that Renegade was having a really hard time figuring out that second checksum in Dead Space 2. But Iddlehands88 and chrome seem to be modding Dead Space 3 on request, so who knows. Maybe there is less security, and maybe an editor is more likely than I think. To be honest, I'm completely ignorant on DS3's save file, so I'm not speaking on any authority on the matter; I'm just making guesses here.
Real time modding, is the way I successfully modded my resources. That is how borderlands 2 was until someone finally cracked the save.