You may need to upload your save for us to look at. When you say corrupt, do you mean it won't load at the start of the game, or you can't load it in the character load screen? I am wondering if it is the CON file (meaning you may have an issue in moving the save back and forth) or your character data (meaning you messed up something).
First, try just copying your save off the drive, then putting it back on without editing. If that ends up corrupt then you have your answer.
If the copy works, try making some small adjustments like setting souls to 100 or something. I remember people having some issues when they tried to set stats to crazy high numbers.
I myself haven't had corruption issues since the first editor, even after completely ruining my inventory on several occasions.