Cheap Ass Gamer got the early scoop on Amazon's Black Friday deals, so you won't have to stand outside of Amazon all night without knowing what you're in line for.(We might not have the best understanding of how Amazon works).
Some of the limited-time Lightning Deals available this Friday will include Assassin's Creed Revelations for $35, and Batman: Arkham City, Battlefield 3, Gears of War 3, Killzone 3, and Madden NFL 12, for $28. So, basically, the same games other retailers will have for $28. That's vaguely suspicious.
Other Lightning Deals include Rayman Origins for $40 on PS3 and Xbox and $30 on Wii, an Xbox 360 with Kinect (plus $50 credit) for $199.99, and an unadorned 4GB Xbox for $139.99.
There are a lot more deals to be found on the list -- you're just going to have to search it yourself for what you're looking for.