Speaking with business giant Forbes, BioWare founders/doctors Greg Zeschuk and Ray Muzyka spoke on the possibility of life after Mass Effect 3, saying that ME3's universe of diverse alien races and planets has struck a chord with the series' audience.While their priorities and resources are currently focused on "nailing it" with ME3, the doctors maintain that possibilities in the future are wide open.
"We do have a desire to continue the Mass Effect franchise," said Muzyka, "and we're working on the details, figuring out what the fans want, figuring out the right way." Given the amount of codex text the series has generated over the years, we don't doubt that there are still stories left to tell in the ME universe.